The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs).
Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all spec
AKT2. AKT3. ALK. AMER1 (FAM123B or Aquarius FIP1L1/CHIC2/PDGFRA Deletion/Fusion Probe är ett kvalitativt där kännedom om rearrangemang av F1P1L1-CHIC2-PDGFRA skulle ha betydelse Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. Neuro Oncol. 7, (2) Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small Gene Name.
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Max rank score in all spec XL PDGFRA BA consists of a green-labeled probe hybridizing proximal to the PDGFRA gene region at 4q12 and an orange-labeled probe hybridizing distal to the PDGFRA gene region at 4q12. Probe maps are created in accordance with the intended purpose of the product. The gene is formed by the fusion of fragments of two other genes called PDGFRA and FIP1L1. This fusion gene then produces a fusion protein which is made up of parts of both the PDGFRA and FIP1L1 proteins. The PDGFRA gene normally codes for a cell membrane receptor protein.
the gene expression of LAT2, a minor tryptophan transporter, which Pretreatment mutational analysis of KIT and PDGFRA optimizes.
On January 9, the Food and Drug Administration (FDA) approved avapritinib (Ayvakit) for some adults with GIST whose tumors have an alteration in a portion of the PDGFRA gene called exon 18. FIP1L1-PDGFRA is an abnormal fusion gene sequence that causes the bone marrow to produce too many eosinophils, a type of white blood cell. It is a rare cause of hypereosinophilia (HE) and hypereosinophilic syndrome (HES). This test detects the FIP1L1-PDGFRA gene sequence to help diagnose these conditions.
2018-07-23
doi: 10.1016/j.ccell.2018.01.021.
Sep 4, 2018 Genetic ablation of Pdgfra+ cells using PdgfrartTA-driven diphtheria toxin (DTA) led to alveolar simplification, demonstrating that these cells are
The PDGFRA gene is also very similar to the KIT gene, and PDGFRA mutations have been found in exons 12, 14 and 18 (corresponding to exons 11, 13 and 17 of
6 days ago Introduction to mutations in GIST. GIST KIT & PDGFRA Mutations The cells in the human body each contain instructions for making the building
Oct 25, 2018 Eosinophilia is a severe disease with increased eosinophil count. The transcript of FIP1L1-PDGFRA fusion gene is a genetic biomarker of
Gene therapy for Duchenne is centered on the goal of successfully introducing a smaller, but efficient version of dystrophin into the muscle cell. PF-06939926 is
Oct 27, 2020 A 35-gene expression profile (GEP) test that classifies melanocytic lesions into categories (benign, intermediate-risk and malignant), has
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platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803]. Gene Synonyms. pdgfra. ID: ZDB-GENE-990415-208; Name: platelet-derived growth factor Orthologous to human PDGFRA (platelet derived growth factor receptor alpha).
Disteche et al. (1989) and Gronwald et al. (1990) confirmed the assignment of PDGFR2 to 4q11-q12 by in situ hybridization and by Southern analysis of a Chinese hamster/human cell hybrid that retained only human chromosome 4. PDGFRA-associated chronic eosinophilic leukemia Genetic abnormalities that involve the PDGFRA gene cause a type of blood cell cancer called PDGFRA-associated chronic eosinophilic leukemia.
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Gastrointestinal stromal tumors (GIST) carrying the D842V activating mutation in the platelet-derived growth factor receptor alpha ( PDGFRA ) gene are a very rare subgroup of GIST (about 10%) known to be resistant to conventional tyrosine kinase inhibitors (TKIs) and to show an indolent behavio …
Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all spec Background: The prognostic impact of the expression profile of genes recurrently amplified in glioblastoma multiforme (GBM) remains controversial.
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Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all spec
PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) is a protein-coding gene. Diseases associated with PDGFRA include fibrosarcoma of bone, and hypereosinophilic syndrome. GO annotations related to this gene include platelet-derived growth factor receptor binding and protein homodimerization activity. FIP1L1-PDGFRA is an abnormal fusion gene sequence that causes the bone marrow to produce too many eosinophils, a type of white blood cell. It is a rare cause of hypereosinophilia (HE) and hypereosinophilic syndrome (HES).